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Genetics and cancer - Mihai Toma, Oana Andrada Alexiu-Toma
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Publisher: Editura Universitara
Author: Mihai Toma, Oana Andrada Alexiu-Toma
ISBN: 978-606-28-1268-3
DOI: https://doi.org/10.5682/9786062812683
Publisher year: 2021
Edition: I
Pages: 100
Product Code:
9786062812683
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The cells of the human body work together structurally and functionally to maintain the body's homeostasis and architecture. Alteration of pathways and signaling mechanisms may influence the rate of cell proliferation and the risk of benign or malignant cell proliferation. Transformed cells acquire new properties that can have a significant impact on local structures or the whole body. Proliferating cells acquire new properties (eg, gain independence from systems that control cell cycle development, develop the ability to invade other tissues) that can alter the body's homeostasis and predispose to pathological conditions that have a poor prognosis.
In this book we try to present the general characteristics of malignant diseases and to particularize them for colorectal cancer. This approach allows us to highlight the problems faced by clinicians and researchers in the biomedical fields that address malignancies.
In this book we try to present the general characteristics of malignant diseases and to particularize them for colorectal cancer. This approach allows us to highlight the problems faced by clinicians and researchers in the biomedical fields that address malignancies.
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Genetics and cancer
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MIHAI TOMA
OANA ANDRADA ALEXIU-TOMA
OANA ANDRADA ALEXIU-TOMA
FOREWORD / 7
Chapter 1. GENETICS AND CANCER / 9
1.1. Epidemiology / 11
1.2. Clinico-pathological aspects / 13
1.3. Etiopathogenesis of the disease / 16
1.4. Diagnostic methods / 37
1.5. Genotype - phenotype correlations / 41
1.6. Treatment / 42
1.7. Perspectives / 42
Chapter 2. COLORECTAL CANCER / 45
2.1. Introduction / 45
2.2. Epidemiology of colorectal cancer / 47
2.3. Clinical description of the disease / 49
2.4. Etiology of the disease / 52
2.4.1. Genetic determinism of the disease / 56
2.4.2. Factors with modulatory effect on disease risk / 64
2.5. Colorectal tumorigenesis - from a genetic and ecological perspective / 66
2.6. Techniques used to identify mutations in the APC / 71 gene
2.6.1. Techniques applied to identify mutations in the APC / 71 gene
2.6.2. Protocol for highlighting mutations in the APC / 73 gene
2.7. APC gene analysis for sporadic forms of colorectal cancer in the Romanian population / 80
2.8. Conclusions / 86
BIBLIOGRAPHY / 87
Chapter 1. GENETICS AND CANCER / 9
1.1. Epidemiology / 11
1.2. Clinico-pathological aspects / 13
1.3. Etiopathogenesis of the disease / 16
1.4. Diagnostic methods / 37
1.5. Genotype - phenotype correlations / 41
1.6. Treatment / 42
1.7. Perspectives / 42
Chapter 2. COLORECTAL CANCER / 45
2.1. Introduction / 45
2.2. Epidemiology of colorectal cancer / 47
2.3. Clinical description of the disease / 49
2.4. Etiology of the disease / 52
2.4.1. Genetic determinism of the disease / 56
2.4.2. Factors with modulatory effect on disease risk / 64
2.5. Colorectal tumorigenesis - from a genetic and ecological perspective / 66
2.6. Techniques used to identify mutations in the APC / 71 gene
2.6.1. Techniques applied to identify mutations in the APC / 71 gene
2.6.2. Protocol for highlighting mutations in the APC / 73 gene
2.7. APC gene analysis for sporadic forms of colorectal cancer in the Romanian population / 80
2.8. Conclusions / 86
BIBLIOGRAPHY / 87
The cells of the human body work together structurally and functionally to maintain the body's homeostasis and architecture. Alteration of pathways and signaling mechanisms may influence the rate of cell proliferation and the risk of benign or malignant cell proliferation. Transformed cells acquire new properties that can have a significant impact on local structures or the whole body. Proliferating cells acquire new properties (eg, gain independence from systems that control cell cycle development, develop the ability to invade other tissues) that can alter the body's homeostasis and predispose to pathological conditions that have a poor prognosis.
In this book we try to present the general characteristics of malignant diseases and to particularize them for colorectal cancer. This approach allows us to highlight the problems faced by clinicians and researchers in the biomedical fields that address malignancies.
In this book we try to present the general characteristics of malignant diseases and to particularize them for colorectal cancer. This approach allows us to highlight the problems faced by clinicians and researchers in the biomedical fields that address malignancies.
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